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Article

Disseminated histiocytoses biomarkers beyond BRAFV600E: frequent expression of PD-L1.

Oncotarget - 14 Aug 2015

Gatalica Zoran, Bilalovic Nurija, Palazzo Juan P, Bender Ryan P, Swensen Jeffrey, Millis Sherri Z, Vranic Semir, Von Hoff Daniel, Arceci Robert J

Abstract excerpt

The histiocytoses are rare tumors characterized by the primary accumulation and tissue infiltration of histiocytes and dendritic cells. Identification of the activating BRAFV600E mutation in Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) cases provided the basis for the treatment with BRAF and/or MEK inhibitors, but additional treatment options are needed. Twenty-four cases of neoplastic...

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Source

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Identifiers

PMID: 26110571
DOI: 10.18632/oncotarget.4378
PMCID: PMC4637323

Genes

ECD
BRAF
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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