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Article

Impact of BRAFV600E mutation on aggressiveness and outcomes in adult clonal histiocytosis.

Frontiers in immunology - 1 Jan 2023

Razanamahery Jerome, Godot Amelie, Leguy-Seguin Vanessa, Samson M, Audia Sylvain, Bonnotte Bernard

Abstract excerpt

Histiocytoses encompass a wide spectrum of diseases, all characterized by tissue infiltration by CD68+ histiocytes. Most adult histiocytoses are considered clonal diseases because they highlight recurrent somatic mutations in the MAP-kinase pathway gene, primarily BRAF. The presence of BRAF mutation is associated with widespread disease in children with Langerhans cell histiocytosis (LCH) or...

Topics

Adult
Child
Humans
Erdheim-Chester Disease
Histiocytosis, Langerhans-Cell
Mutation
Proto-Oncogene Proteins B-raf
Retrospective Studies
Histiocytosis

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37809108
DOI: 10.3389/fimmu.2023.1260193
PMCID: PMC10556468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-37809108-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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