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Article

Impact of BRAFV600E mutation on aggressiveness and outcomes in adult clonal histiocytosis.

Frontiers in immunology - 1 Jan 2023

Razanamahery Jerome, Godot Amelie, Leguy-Seguin Vanessa, Samson M, Audia Sylvain, Bonnotte Bernard

Abstract excerpt

Histiocytoses encompass a wide spectrum of diseases, all characterized by tissue infiltration by CD68+ histiocytes. Most adult histiocytoses are considered clonal diseases because they highlight recurrent somatic mutations in the MAP-kinase pathway gene, primarily BRAF. The presence of BRAF mutation is associated with widespread disease in children with Langerhans cell histiocytosis (LCH) or...

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Identifiers

PMID: 37809108
DOI: 10.3389/fimmu.2023.1260193
PMCID: PMC10556468

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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