Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans

10 Jun 2015

Abstract excerpt

BACKGROUND: Mitochondrial alterations have been observed in subjects with metabolic disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest aberrant glucose and lipid levels, and impaired insulin signaling might lead to mitochondrial changes. However, the molecular mechanism underlying mitochondrial aberrance remains largely unexplored in human subjects. RESULTS: Here we show...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Epigenetics and DNA Methylation
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26110043
DOI: 10.1186/s13148-015-0093-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humansPMID 26110043Read ↗

Mitochondrial alteration in type 2 diabetes and obesity: An epigenetic linkSemantic proximity Read ↗

Mitochondrial DNA oxidation and content in different metabolic phenotypes of women with polycystic ovary syndrome.Semantic proximity Read ↗

Changes in Mitochondrial Epigenome in Type 2 Diabetes MellitusSemantic proximity Read ↗

Relationship of Mitochondrial DNA Oxidation and Content with Metabolic Syndrome and Cardiovascular Risk in Obesity Phenotypes.Semantic proximity Read ↗

Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistanceSemantic proximity Read ↗

LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypesSemantic proximity Read ↗

A Decreased Mitochondrial DNA Content Is Related to Insulin Resistance in AdolescentsSemantic proximity Read ↗

From Normal to Obesity and Back: The Associations between Mitochondrial DNA Copy Number, Gender, and Body Mass IndexSemantic proximity Read ↗

Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changesSemantic proximity Read ↗

Mitochondrial DNA Copy Number and Risk of Diabetes Mellitus and Metabolic SyndromeSemantic proximity Read ↗

Epigenetic Regulation of Insulin Resistance in Nonalcoholic Fatty Liver DiseaseSemantic proximity Read ↗

Peripheral Blood Mitochondrial DNA Content Is Related to Insulin Sensitivity in Offspring of Type 2 Diabetic PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.