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Article

Epigenetic Regulation of Insulin Resistance in Nonalcoholic Fatty Liver Disease

22 Aug 2010

Abstract excerpt

UNLABELLED: Insulin resistance (IR) and mitochondrial dysfunction play a central role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD). We hypothesized that genetic factors and epigenetic modifications occurring in the liver contribute to the IR phenotype. We specifically examined whether fatty liver and IR are modified by hepatic DNA methylation of the peroxisome proliferator-activated receptor...

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Share to Epigenetics and DNA Methylation
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PMID: 20890895
DOI: 10.1002/hep.23927

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