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A Decreased Mitochondrial DNA Content Is Related to Insulin Resistance in Adolescents

1 May 2008

Abstract excerpt

The aim of this study was to investigate whether mitochondrial DNA (mtDNA) content is associated with insulin resistance (IR) in a sample of adolescents with features of metabolic syndrome. We further studied the link between polymorphisms in three genes involved in mitochondrial biogenesis and the presence of deleted mtDNA and mtDNA content. Data and blood samples were collected from 175 adolescents out of a...

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PMID: 18451773
DOI: 10.1038/oby.2008.253

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