Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins.

PLoS genetics - 1 Jun 2015

Starks Rachel D, Beyer Andreas M, Guo Deng Fu, Boland Lauren, Zhang Qihong, Sheffield Val C, Rahmouni Kamal

Abstract excerpt

Insulin and its receptor are critical for the regulation of metabolic functions, but the mechanisms underlying insulin receptor (IR) trafficking to the plasma membrane are not well understood. Here, we show that Bardet Biedl Syndrome (BBS) proteins are necessary for IR localization to the cell surface. We demonstrate that the IR interacts physically with BBS proteins, and reducing the expression of BBS proteins...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bardet-Biedl Syndrome
Share to Cell Membrane
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Insulin

Share to Microtubule-Associated Proteins

Share to Protein Transport

Share to Receptor, Insulin

Source

Open in PubMed Open full text

Identifiers

PMID: 26103456
DOI: 10.1371/journal.pgen.1005311
PMCID: PMC4478011

Genes

BBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins.PMID 26103456Read ↗

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signalingSemantic proximity Read ↗

Molecular mechanisms of the obesity associated with Bardet-Biedl syndrome: An update.Semantic proximity Read ↗

GAS6 and AXL promote insulin resistance by rewiring insulin signaling and increasing insulin receptor trafficking to endosomesSemantic proximity Read ↗

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.Semantic proximity Read ↗

Adipose tissue function and insulin sensitivity in syndromic obesity of Bardet-Biedl SyndromeSemantic proximity Read ↗

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic isletsSemantic proximity Read ↗

Kin of IRRE-like Protein 2 Is a Phosphorylated Glycoprotein That Regulates Basal Insulin Secretion.Semantic proximity Read ↗

The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis.Semantic proximity Read ↗

Ectopic expression of human BBS4 can rescue Bardet-Biedl syndrome phenotypes in Bbs4 null mice.Semantic proximity Read ↗

Subcellular Localization of ALMS1 Supports Involvement of Centrosome and Basal Body Dysfunction in the Pathogenesis of Obesity, Insulin Resistance, and Type 2 DiabetesSemantic proximity Read ↗

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse β cellsSemantic proximity Read ↗

Grb10 and Grb14: enigmatic regulators of insulin action--and more?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.