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Article

KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.

PloS one - 1 Jan 2015

Klinke Olaf Karl, Mizani Tuba, Baldwin Gouri, Bancel Brigitte, Devouassoux-Shisheboran Mojgan, Scoazec Jean-Yves, Bringuier Pierre-Paul, Feederle Regina, Jauch Anna, Hinderhofer Katrin, Taniere Philippe, Delecluse Henri-Jacques

Abstract excerpt

The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-genome sequencing, comparative genomic hybridisation and methylation profiling. The studied tumour harboured two...

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Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gastrointestinal Stromal Tumors

Share to KIT gene

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Share to Polymorphism, Single Nucleotide

Share to Proto-Oncogene Proteins c-kit

Source

Open in PubMed Open full text

Identifiers

PMID: 26102504
DOI: 10.1371/journal.pone.0130149
PMCID: PMC4477893

Genes

KIT
BUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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