Article
Multilineage dysplasia as assessed by immunophenotype has no impact on clinical-biological features and outcome of NPM1-mutated acute myeloid leukemia.
Experimental hematology - 1 Oct 2015
Mannelli Francesco, Ponziani Vanessa, Bonetti Maria Ida, Bencini Sara, Cutini Ilaria, Gianfaldoni Giacomo, Scappini Barbara, Pancani Fabiana, Rondelli Tommaso, Benelli Matteo, Caporale Roberto, Grazia Gelli Anna Maria, Peruzzi Benedetta, Longo Giovanni, Bosi Alberto
Abstract excerpt
The presence of multilineage dysplasia (MLD) by morphology at diagnosis in acute myeloid leukemia (AML) defines a separate subset in the World Health Organization classification with still-debated prognostic value. A major controversy concerns MLD's role in NPM1-mutated (NPM1⁺) AML, which correlates with good prognosis. We used flow cytometry (FC), an emerging technique for assessing dysplasia, to investigate MLD...
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