Article
Generating new prions by targeted mutation or segment duplication.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jul 2015
Paul Kacy R, Hendrich Connor G, Waechter Aubrey, Harman Madison R, Ross Eric D
Abstract excerpt
Yeasts contain various protein-based genetic elements, termed prions, that result from the structural conversion of proteins into self-propagating amyloid forms. Most yeast prion proteins contain glutamine/asparagine (Q/N)-rich prion domains that drive prion activity. Here, we explore two mechanisms by which new prion domains could evolve. First, it has been proposed that mutation and natural selection will tend...
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