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Article

Genetic drift of human coronavirus OC43 spike gene during adaptive evolution.

Scientific reports - 22 Jun 2015

Ren Lili, Zhang Yue, Li Jianguo, Xiao Yan, Zhang Jing, Wang Ying, Chen Lan, Paranhos-Baccalà Gláucia, Wang Jianwei

Abstract excerpt

Coronaviruses (CoVs) continuously threaten human health. However, to date, the evolutionary mechanisms that govern CoV strain persistence in human populations have not been fully understood. In this study, we characterized the evolution of the major antigen-spike (S) gene in the most prevalent human coronavirus (HCoV) OC43 using phylogenetic and phylodynamic analysis. Among the five known HCoV-OC43 genotypes (A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26099036
DOI: 10.1038/srep11451
PMCID: PMC4476415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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