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Article

Pandemic-driven immune imprinting accelerates evolution of human coronavirus OC43.

PLoS neglected tropical diseases - 1 Mar 2026

Lu Shuiping, Shen Qi, Wang Huanru, Cai Mingyi, Hu Jingjing, Li Yi, Wang Yuxi, Yuan Feng, Xu Qingyuan, Chen Weijie, Wu Yitian, Xiong Jiasheng, Teng Zheng, Tang Mengting, Xiong Chenglong

Abstract excerpt

Global pandemic interventions have reshaped host-virus dynamics, potentially altering the evolution of endemic pathogens. Here, we report accelerated genomic evolution of human coronavirus OC43 (HCoV-OC43)-a close relative of pandemic-associated coronaviruses-following recent worldwide epidemiological shifts. Bayesian analysis of longitudinal surveillance data revealed a 3.76-fold increase (8.9403 × 10 ⁻ ⁴...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41843571
DOI: 10.1371/journal.pntd.0014109
PMCID: PMC12994797

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HPD

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