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Article

Whether Alzheimer's diseases related genes also differently express in the hippocampus of Ts65Dn mice?

International journal of clinical and experimental pathology - 1 Jan 2015

Zhang Bin, Wang Qiuwei, Miao Tingting, Yu Bin, Yuan Pei, Kong Jing, Lu Beiyi

Abstract excerpt

BACKGROUND: Down syndrome is a condition which extra genetic material causes delays in child development, both mentally and physically. Strengthening the study of the neural defects of DS is of great significance. METHODS: Ts65Dn mice were used in this study. We removed the brain and isolated their hippocampus. We customized 54 genes in one PCR arrays, included some important genes related to Alzheimer's disease....

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Source

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Identifiers

PMID: 26097601
PMCID: PMC4466988

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Whether Alzheimer's diseases related genes also differently express in the hippocampus of Ts65Dn mice?PMID 26097601Read ↗

Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer’s disease (AD)Semantic proximity Read ↗

Temporal and brain region‐specific elevations of soluble Amyloid‐β40‐42 in the Ts65Dn mouse model of Down syndrome and Alzheimer’s diseaseSemantic proximity Read ↗

Potassium channel regulators are differentially expressed in hippocampi of Ts65Dn and Tc1 Down syndrome mouse modelsSemantic proximity Read ↗

Analysis of Adult Cerebral Cortex and Hippocampus Transcriptomes Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of D own SyndromeSemantic proximity Read ↗

Abnormal expression of synaptic proteins and neurotrophin-3 in the down syndrome mouse model Ts65DnSemantic proximity Read ↗

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down SyndromeSemantic proximity Read ↗

CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementationSemantic proximity Read ↗

Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer’s DiseaseSemantic proximity Read ↗

Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in a 6-month old Mouse Model of Down Syndrome and Alzheimer’s DiseaseSemantic proximity Read ↗

Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.Semantic proximity Read ↗

microRNAs expression correlates with levels of APP, DYRK1A, hyperphosphorylated Tau and BDNF in the hippocampus of a mouse model for Down syndrome during ageingSemantic proximity Read ↗

Regulation of gene expression by the APP family in the adult cerebral cortexSemantic proximity Read ↗

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