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Article

Role of pharmacogenetics of drug-metabolizing enzymes in treating osteosarcoma.

Expert opinion on drug metabolism & toxicology - 1 Jan 2015

Hattinger Claudia Maria, Serra Massimo

Abstract excerpt

INTRODUCTION: Drug-metabolizing enzymes (DMEs) biotransform several toxins and xenobiotics in both tumor and normal cells, resulting in either their detoxification or their activation. Since DMEs also metabolize several chemotherapeutic drugs, they can significantly influence tumor response to chemotherapy and susceptibility of normal tissues to collateral toxicity of anticancer treatments. AREAS COVERED: This...

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Identifiers

PMID: 26095223
DOI: 10.1517/17425255.2015.1060220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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