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Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

16 Feb 2021

Abstract excerpt

the transport of these substrates is partitioned across two paralogs: PIC2 and MIR1. To understand the ancestral state of copper and phosphate transport in mitochondria, we explored the evolutionary relationships of PIC2 and MIR1 orthologs across the eukaryotic tree of life. Phylogenetic analyses revealed that PIC2-like and MIR1-like orthologs are present in all major eukaryotic supergroups, indicating an ancient...

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PMID: 33591272
DOI: 10.7554/elife.64690

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