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Article

Fibrotic Effects of Arecoline<i>N</i>-Oxide in Oral Potentially Malignant Disorders

10 Jun 2015

Abstract excerpt

The metabolites of environmental chemicals play key roles in carcinogenesis. Areca nut is strongly associated with the development of oral potentially malignant disorders (OPMD) or cancer. The main alkaloid in the areca nut is arecoline, which is highly cytotoxic and genotoxic. Arecoline N-oxide, a metabolite of areca nut alkaloids, which has been identified in animal urine, has been shown to induce mutagenicity...

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PMID: 26061808
DOI: 10.1021/acs.jafc.5b01351

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Related research

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Fibrotic Effects of Arecoline<i>N</i>-Oxide in Oral Potentially Malignant DisordersPMID 26061808Read ↗

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miR-203 inhibits arecoline-induced epithelial-mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family member 1 in oral submucous fibrosisSemantic proximity Read ↗

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Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human epithelial cellsSemantic proximity Read ↗

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