Article
DNA methylation dynamics in human carotid plaques after cerebrovascular events.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2015
Zaina Silvio, Gonçalves Isabel, Carmona F Javier, Gomez Antonio, Heyn Holger, Mollet Inês G, Moran Sebastian, Varol Nuray, Esteller Manel
Abstract excerpt
OBJECTIVE: To understand whether cerebrovascular events, a major complication of atherosclerosis, are associated with any specific DNA methylation changes in the carotid plaque. APPROACH AND RESULTS: We profiled the DNA methylomes of human symptomatic carotid plaques obtained from patients who had cerebrovascular events (n=19) and asymptomatic counterparts (n=19) with a high-density microarray (≈485 000 CpG...
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