Article
High-density lipoproteins reduce endothelial-to-mesenchymal transition.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2015
Spillmann Frank, Miteva Kapka, Pieske Burkert, Tschöpe Carsten, Van Linthout Sophie
Abstract excerpt
OBJECTIVE: Endothelial-to-mesenchymal transition is an inflammation-induced process by which endothelial cells can transdifferentiate into fibroblasts. Based on the endothelial-protective and antifibrotic effects of high-density lipoproteins (HDL), we aimed to investigate whether HDL can reduce endothelial-to-mesenchymal transition. APPROACH AND RESULTS: Therefore, human aortic endothelial cells were stimulated...
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