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Article

Association of Polymorphism of Neuronal Nitric Oxide Synthase Gene with Risk to Parkinson's Disease.

Molecular neurobiology - 1 Jul 2016

Gupta Satya Prakash, Kamal Ritul, Mishra Sarad Kumar, Singh Maneesh Kumar, Shukla Rakesh, Singh Mahendra Pratap

Abstract excerpt

Environmental factors are implicated in aging as well as genetic predisposition-induced Parkinson's disease (PD) pathogenesis. Wrongdoers increase oxidative stress and nitrosative burden, which eventually degenerate the nigrostriatal dopaminergic neurons. Inhibition of the expression of nitric oxide synthase (NOS), an enzyme responsible for nitric oxide (NO) biosynthesis, prevents the demise of the nigrostriatal...

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PMID: 26081147
DOI: 10.1007/s12035-015-9274-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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