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Article

Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.

Human molecular genetics - 1 Jan 2003

Levecque Clotilde, Elbaz Alexis, Clavel Jacqueline, Richard Florence, Vidal Jean-Sébastien, Amouyel Philippe, Tzourio Christophe, Alpérovitch Annick, Chartier-Harlin Marie-Christine

Abstract excerpt

Excess of nitric oxide (NO) has been shown to exert neurotoxic impacts in the brain. Moreover, inhibition of two NO-synthesizing enzymes, neuronal NOS (nNOS) and inducible NOS (iNOS), displays neuroprotective effects in the MPTP model of Parkinson's disease (PD). These data suggest a possible involvement of NOS as factors controlling the resistance of the nigral dopaminergic neurons to environmental insults....

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Identifiers

PMID: 12490535
DOI: 10.1093/hmg/ddg009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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