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Article

Mapping fast protein folding with multiple-site fluorescent probes.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jun 2015

Prigozhin Maxim B, Chao Shu-Han, Sukenik Shahar, Pogorelov Taras V, Gruebele Martin

Abstract excerpt

Fast protein folding involves complex dynamics in many degrees of freedom, yet microsecond folding experiments provide only low-resolution structural information. We enhance the structural resolution of the five-helix bundle protein λ6-85 by engineering into it three fluorescent tryptophan-tyrosine contact probes. The probes report on distances between three different helix pairs: 1-2, 1-3, and 3-2. Temperature...

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Identifiers

PMID: 26080403
DOI: 10.1073/pnas.1422683112
PMCID: PMC4491763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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