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Article

Epigenetic modifications of the glucocorticoid receptor gene are associated with the vulnerability to psychopathology in childhood maltreatment.

Translational psychiatry - 26 May 2015

Radtke K M, Schauer M, Gunter H M, Ruf-Leuschner M, Sill J, Meyer A, Elbert T

Abstract excerpt

Stress, particularly when experienced early in life, can have profound implications for mental health. Previous research covering various tissues such as the brain, suggests that the detrimental impact of early-life stress (ELS) on mental health is mediated via epigenetic modifications including DNA methylation. Genes of the hypothalamic-pituitary-adrenal axis--in particular, the glucocorticoid receptor (hGR)...

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Identifiers

PMID: 26080088
DOI: 10.1038/tp.2015.63
PMCID: PMC4471294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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