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Methylation of exons 1D, 1F, and 1Hof the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children

1 May 2015

Abstract excerpt

Epigenetic modifications to the genome are a key mechanism involved in the biological encoding of experience. Animal studies and a growing body of literature in humans have shown that early adversity is linked to methylation of the gene for the glucocorticoid receptor (GR), which is a key regulator of the hypothalamic-pituitary-adrenal axis as well as a broad range of physiological systems including metabolic and...

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PMID: 25997773
DOI: 10.1017/s0954579415000176

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