Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD.

Psychopharmacology - 1 Oct 2010

Yehuda Rachel, Flory Janine D, Pratchett Laura C, Buxbaum Joseph, Ising Marcus, Holsboer Florian

Abstract excerpt

RATIONALE: Early Life Stress (ELS) increases risk for both adult traumatization and posttraumatic stress disorder (PTSD). Adult PTSD may also reflect a continuation of a response to an earlier exposure to adversity. Given similarities between neuroendocrine aspects of PTSD and ELS, such as in reduced cortisol signaling and glucocorticoid receptor (GR) responsiveness, some aspects of the biology of PTSD may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hydrocortisone

Share to Models, Psychological

Share to Receptors, Glucocorticoid

Share to Risk Factors

Share to Stress Disorders, Post-Traumatic

Share to Stress, Psychological

Source

Identifiers

PMID: 20706708
DOI: 10.1007/s00213-010-1969-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD.PMID 20706708Read ↗

Early Life Stress as a Predictor of Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress DisorderSemantic proximity Read ↗

Epigenomic Mechanisms of Early Adversity and HPA Dysfunction: Considerations for PTSD ResearchSemantic proximity Read ↗

Recent Genetics and Epigenetics Approaches to PTSD.Semantic proximity Read ↗

Epigenetic Modifications in Stress Response Genes Associated With Childhood TraumaSemantic proximity Read ↗

Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics.Semantic proximity Read ↗

Epigenetic Risk Factors in PTSD and DepressionSemantic proximity Read ↗

The role of genes in defining a molecular biology of PTSD.Semantic proximity Read ↗

Epigenetic Alterations Associated with War Trauma and Childhood MaltreatmentSemantic proximity Read ↗

A Review of Epigenetics of PTSD in Comorbid Psychiatric ConditionsSemantic proximity Read ↗

Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disordersSemantic proximity Read ↗

Gene × environment vulnerability factors for PTSD: the HPA-axis.Semantic proximity Read ↗

Genetic approaches for the study of PTSD: Advances and challenges.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.