Article
The Associations between RNA Splicing Complex Gene SF3A1 Polymorphisms and Colorectal Cancer Risk in a Chinese Population.
PloS one - 1 Jan 2015
Chen Xiaohua, Du Hua, Liu Binjian, Zou Li, Chen Wei, Yang Yang, Zhu Ying, Gong Yajie, Tian Jianbo, Li Feng, Zhong Shan
Abstract excerpt
BACKGROUND: Aberrant alternative splicing included alterations in components of the mRNA splicing machinery often occurred in colon cancer. However, the role of SF3A1, one key component of the mRNA splicing machinery, on colorectal cancer (CRC) risk was still not elucidated. METHOD AND FINDINGS: We performed a hospital-based case-control study containing 801 CRC patients and 817 cancer-free controls to examine...
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