Article
A responsive human triple-culture model of the air-blood barrier: incorporation of different macrophage phenotypes.
Journal of tissue engineering and regenerative medicine - 1 Apr 2017
Kasper Jennifer Y, Hermanns Maria I, Unger Ronald E, Kirkpatrick C James
Abstract excerpt
Current pulmonary research underlines the relevance of the alveolar macrophage (AM) integrated in multicellular co-culture-systems of the respiratory tract to unravel, for example, the mechanisms of tissue regeneration. AMs demonstrate a specific functionality, as they inhabit a unique microenvironment with high oxygen levels and exposure to external hazards. Healthy AMs display an anti-inflammatory phenotype,...
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