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Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella

28 May 2015

Abstract excerpt

Fluoroquinolones are broad-spectrum antibiotics that inhibit bacterial DNA gyrase and topoisomerase activity, which can cause DNA damage and result in bacterial cell death. In response to DNA damage, bacteria induce an SOS response to stimulate DNA repair. However, the SOS response may also induce prophage with production of infectious virions. Salmonella strains typically contain multiple prophages, and certain...

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PMID: 26078016
DOI: 10.1016/j.ijantimicag.2015.04.008

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