Article
Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2015
Qamar Arman, Khetarpal Sumeet A, Khera Amit V, Qasim Atif, Rader Daniel J, Reilly Muredach P
Abstract excerpt
OBJECTIVE: Triglyceride-rich lipoproteins have emerged as causal risk factors for developing coronary heart disease independent of low-density lipoprotein cholesterol levels. Apolipoprotein C-III (ApoC-III) modulates triglyceride-rich lipoprotein metabolism through inhibition of lipoprotein lipase and hepatic uptake of triglyceride-rich lipoproteins. Mutations causing loss-of-function of ApoC-III lower...
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