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Article

PNPLA3 rs738409 risk genotype decouples TyG index from HOMA2-IR and intrahepatic lipid content.

Cardiovascular diabetology - 21 Mar 2023

Nádasdi Ákos, Gál Viktor, Masszi Tamás, Somogyi Anikó, Firneisz Gábor

Abstract excerpt

BACKGROUND: Recent reports suggested a different predictive value for TyG index compared to HOMA-IR in coronary artery calcification (CAC) and other atherosclerotic outcomes, despite that both indices are proposed as surrogate markers of insulin resistance. We hypothesized a key role for liver pathology as an explanation and therefore assessed the relationship among the two indices and the intrahepatic lipid...

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Identifiers

PMID: 36944955
DOI: 10.1186/s12933-023-01792-w
PMCID: PMC10031960

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