Article
In Vivo Selection of Pan-Drug Resistant Acinetobacter baumannii during Antibiotic Treatment.
Yonsei medical journal - 1 Jul 2015
Kim Yoonjung, Bae Il Kwon, Jeong Seok Hoon, Yong Dongeun, Lee Kyungwon
Abstract excerpt
PURPOSE: Colistin resistance in Acinetobacter baumannii (A. baumannii) is mediated by a complete loss of lipopolysaccharide production via mutations in lpxA, lpxC, and lpxD gene or lipid A modifications via mutations in the pmrA and pmrB genes. However, the exact mechanism of therapy-induced colistin resistance in A. baumannii is not well understood. MATERIALS AND METHODS: We investigated the genotypic and...
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