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Article

Gene-gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.

BMJ open - 11 Jun 2015

Su Sui-Lung, Yang Hsin-Yi, Lee Herng-Sheng, Huang Guo-Shu, Lee Chian-Her, Liu Wan-Shan, Wang Chih-Chien, Peng Yi-Jen, Lai Ching-Huang, Chen Ching-Yang, Lin Chin, Pan Yu-Ting, Salter Donald M, Chen Hsiang-Cheng

Abstract excerpt

OBJECTIVE: Transforming growth factor/Smad family member 3 (TGF)-β/Smad3 signalling is essential for maintaining articular cartilage. A relationship between the genetic variants of TGF-β itself, TGF-β signalling and binding molecules, and osteoarthritis (OA) has been reported. Although variants of candidate genes have become prime targets for genetic analysis, their detailed interplay has not been documented. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26068512
DOI: 10.1136/bmjopen-2015-007931
PMCID: PMC4466616

Genes

TIMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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