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Article

High-throughput screening of caterpillars as a platform to study host–microbe interactions and enteric immunity

24 Nov 2022

Abstract excerpt

Mammalian models of human disease are expensive and subject to ethical restrictions. Here, we present an independent platform for high-throughput screening, using larvae of the tobacco hornworm Manduca sexta, combining diagnostic imaging modalities for a comprehensive characterization of aberrant phenotypes. For validation, we use bacterial/chemical-induced gut inflammation to generate a colitis-like phenotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36433960
DOI: 10.1038/s41467-022-34865-7

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