Article
Plasma Proteomic Profiling in Hereditary Breast Cancer Reveals a BRCA1-Specific Signature: Diagnostic and Functional Implications.
PloS one - 1 Jan 2015
Scumaci Domenica, Tammè Laura, Fiumara Claudia Vincenza, Pappaianni Giusi, Concolino Antonio, Leone Emanuela, Faniello Maria Concetta, Quaresima Barbara, Ricevuto Enrico, Costanzo Francesco Saverio, Cuda Giovanni
Abstract excerpt
BACKGROUND: Breast cancer (BC) is a leading cause of death among women. Among the major risk factors, an important role is played by familial history of BC. Germ-line mutations in BRCA1/2 genes account for most of the hereditary breast and/or ovarian cancers. Gene expression profiling studies have disclosed specific molecular signatures for BRCA1/2-related breast tumors as compared to sporadic cases, which might...
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