Methylation of KvDMR1 involved in regulating the imprinting of CDKN1C gene in cattle.

doi:10.1111/age.12297

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Article

Methylation of KvDMR1 involved in regulating the imprinting of CDKN1C gene in cattle.

Animal genetics - 1 Aug 2015

Wang Mengnan, Li Dongjie, Zhang Mingyue, Yang Wenzhi, Cui Yali, Li Shijie

Abstract excerpt

The CDKN1C gene encodes a cyclin-dependent kinase inhibitor and is one of the key genes involved in the development of Beckwith-Wiedemann syndrome and cancer. In this study, using a direct sequencing approach based on a single nucleotide polymorphism (SNP) at genomic DNA and cDNA levels, we show that CDKN1C exhibits monoallelic expression in all seven studied organs (heart, liver, spleen, lung, kidney, muscle and...

Topics

Alleles
Animals
Cattle
Cyclin-Dependent Kinase Inhibitor p57
DNA Methylation
Genomic Imprinting
Molecular Sequence Data
Polymorphism, Single Nucleotide
Potassium Channels, Voltage-Gated
Sequence Analysis, DNA

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Identifiers

PMID: 26059028
DOI: 10.1111/age.12297

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