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Article

Methylation of KvDMR1 involved in regulating the imprinting of CDKN1C gene in cattle.

Animal genetics - 1 Aug 2015

Wang Mengnan, Li Dongjie, Zhang Mingyue, Yang Wenzhi, Cui Yali, Li Shijie

Abstract excerpt

The CDKN1C gene encodes a cyclin-dependent kinase inhibitor and is one of the key genes involved in the development of Beckwith-Wiedemann syndrome and cancer. In this study, using a direct sequencing approach based on a single nucleotide polymorphism (SNP) at genomic DNA and cDNA levels, we show that CDKN1C exhibits monoallelic expression in all seven studied organs (heart, liver, spleen, lung, kidney, muscle and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26059028
DOI: 10.1111/age.12297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation of KvDMR1 involved in regulating the imprinting of CDKN1C gene in cattle.PMID 26059028Read ↗

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Methylation at mouse Cdkn1c is acquired during postimplantation development and functions to maintain imprinted expression.Semantic proximity Read ↗

Aberrant CpG methylation of the imprinting control region KvDMR1 detected in assisted reproductive technology-produced calves and pathogenesis of large offspring syndromeSemantic proximity Read ↗

Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovineSemantic proximity Read ↗

Silencing of <i>CDKN1C</i> (<i>p57<sup>KIP2</sup> </i>) is associated with hypomethylation at KvDMR1 in Beckwith–Wiedemann syndromeSemantic proximity Read ↗

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Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndromeSemantic proximity Read ↗

Domain regulation of imprinting cluster in Kip2/Lit1 subdomain on mouse chromosome 7F4/F5: large-scale DNA methylation analysis reveals that DMR-Lit1 is a putative imprinting control region.Semantic proximity Read ↗

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