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Article

Evolution of the CDKN1C-KCNQ1 imprinted domain

29 May 2008

Abstract excerpt

BACKGROUND: Genomic imprinting occurs in both marsupial and eutherian mammals. The CDKN1C and IGF2 genes are both imprinted and syntenic in the mouse and human, but in marsupials only IGF2 is imprinted. This study examines the evolution of features that, in eutherians, regulate CDKN1C imprinting. RESULTS: Despite the absence of imprinting, CDKN1C protein was present in the tammar wallaby placenta. Genomic...

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Share to Epigenetics and DNA Methylation
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PMID: 18510768
DOI: 10.1186/1471-2148-8-163

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