Methylation pattern at the KvDMR in a child with Beckwith–Wiedemann syndrome conceived by ICSI

Abstract excerpt

To the Editor: Epigenetic modifications are reversible and heritable changes in DNA packing and chromatin structure that can affect the access of transcription factors and gene expression without involving the DNA sequence. Genomic imprinting is an epigenetic mechanism in which gene expression depends on the parental origin (paternal or maternal). Approximately 60 imprinted genes have been identified in mammals...

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