Article
Cell growth of wall-free L-form bacteria is limited by oxidative damage.
Current biology : CB - 15 Jun 2015
Kawai Yoshikazu, Mercier Romain, Wu Ling Juan, Domínguez-Cuevas Patricia, Oshima Taku, Errington Jeff
Abstract excerpt
The peptidoglycan (PG) cell wall is a defining feature of the bacterial lineage and an important target for antibiotics, such as β-lactams and glycopeptides. Nevertheless, many bacteria are capable of switching into a cell-wall-deficient state, called the "L-form" [1-3]. These variants have been classically identified as antibiotic-resistant forms in association with a wide range of infectious diseases [4]....
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