Article
Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.
Oncogene - 10 Mar 2016
O'Leary L, van der Sloot A M, Reis C R, Deegan S, Ryan A E, Dhami S P S, Murillo L S, Cool R H, Correa de Sampaio P, Thompson K, Murphy G, Quax W J, Serrano L, Samali A, Szegezdi E
Abstract excerpt
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is a death ligand cytokine known for its cytotoxic activity against malignantly transformed cells. TRAIL induces cell death through binding to death receptors DR4 and DR5. The inhibitory decoy receptors (DcR1 and DcR2) co-expressed with death receptor 4 (DR4)/DR5 on the same cell can block the transmission of the apoptotic signal. Here, we show that...
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