Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Applying genetics in inflammatory disease drug discovery.

Drug discovery today - 1 Oct 2015

Folkersen Lasse, Biswas Shameek, Frederiksen Klaus Stensgaard, Keller Pernille, Fox Brian, Fleckner Jan

Abstract excerpt

Recent groundbreaking work in genetics has identified thousands of small-effect genetic variants throughout the genome that are associated with almost all major diseases. These genome-wide association studies (GWAS) are often proposed as a source of future medical breakthroughs. However, with several notable exceptions, the journey from a small-effect genetic variant to a functional drug has proven arduous, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents
Share to Drug Design
Share to Drug Discovery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Inflammation

Share to Molecular Targeted Therapy

Source

Identifiers

PMID: 26050580
DOI: 10.1016/j.drudis.2015.05.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Applying genetics in inflammatory disease drug discovery.PMID 26050580Read ↗

Genetics in drug discovery and development: challenge and promise of individualizing treatment in common complex diseases.Semantic proximity Read ↗

From the era of genome analysis to the era of genomic drug discovery: a pioneering example of rheumatoid arthritis.Semantic proximity Read ↗

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology.Semantic proximity Read ↗

Bringing genome-wide association findings into clinical use.Semantic proximity Read ↗

Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.Semantic proximity Read ↗

Integrative Approaches to Understanding the Pathogenic Role of Genetic Variation in Rheumatic Diseases.Semantic proximity Read ↗

Human genetics contributes to the understanding of disease pathophysiology and drug discovery.Semantic proximity Read ↗

Current Developments of Clinical Sequencing and the Clinical Utility of Polygenic Risk Scores in Inflammatory Diseases.Semantic proximity Read ↗

Leveraging human genetics to develop future therapeutic strategies in rheumatoid arthritis.Semantic proximity Read ↗

The genetics of health.Semantic proximity Read ↗

Advancing the use of genome-wide association studies for drug repurposing.Semantic proximity Read ↗

Leveraging human genetics to guide drug target discovery.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.