Article
Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.
Expert review of molecular diagnostics - 1 Jul 2007
Grant Struan F A, Hakonarson Hakon
Abstract excerpt
Genetic diversity, most notably through single nucleotide polymorphisms and copy-number variation, together with specific environmental exposures, contributes to both disease susceptibility and drug response variability. It has proved difficult to isolate disease genes that confer susceptibility to complex disorders, and as a consequence, even fewer genetic variants that influence clinical drug responsiveness...
Topics
- Genetic Predisposition to Disease
- Genome, Human
- Genomics
- Genotype
- Humans
- Pharmacogenetics