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Article

Integrative Approaches to Understanding the Pathogenic Role of Genetic Variation in Rheumatic Diseases.

Rheumatic diseases clinics of North America - 1 Aug 2017

Laufer Vincent A, Chen Jake Y, Langefeld Carl D, Bridges S Louis

Abstract excerpt

The use of high-throughput omics may help to understand the contribution of genetic variants to the pathogenesis of rheumatic diseases. We discuss the concept of missing heritability: that genetic variants do not explain the heritability of rheumatoid arthritis and related rheumatologic conditions. In addition to an overview of how integrative data analysis can lead to novel insights into mechanisms of rheumatic...

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PMID: 28711145
DOI: 10.1016/j.rdc.2017.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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