Article
The effect of CYP19 and COMT polymorphisms on exercise-induced fat loss in postmenopausal women.
Obesity research - 1 Jun 2004
Tworoger Shelley S, Chubak Jessica, Aiello Erin J, Yasui Yutaka, Ulrich Cornelia M, Farin Federico M, Stapleton Patricia L, Irwin Melinda L, Potter John D, Schwartz Robert S, McTiernan Anne
Abstract excerpt
OBJECTIVE: To examine whether genetic polymorphisms in CYP19 [intron 4 (TTTA)n; n = 7 to 13 and a 3-base pair deletion, which is in strong linkage disequilibrium with the seven repeat] and COMT (Val108/158Met) modified the change in BMI, total and percentage body fat, or subcutaneous and intra-abdominal fat during a year-long exercise intervention trial. These genes metabolize estrogens and androgens, which are...
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