Article
Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors.
Breast cancer research : BCR - 20 Jan 2011
Mao Jun J, Su H Irene, Feng Rui, Donelson Michelle L, Aplenc Richard, Rebbeck Timothy R, Stanczyk Frank, DeMichele Angela
Abstract excerpt
INTRODUCTION: Aromatase inhibitor-associated arthralgia (AIAA) is a common and often debilitating symptom in breast cancer survivors. Since joint symptoms have been related to estrogen deprivation through the menopausal transition, we hypothesized that genetic polymorphisms in CYP19A1, the final enzyme in estrogen synthesis, may be associated with the occurrence of AIAA. METHODS: We performed a cross-sectional...
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