Article
Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled trial.
BMC cancer - 21 Apr 2016
Kopp Tine Iskov, Jensen Ditte Marie, Ravn-Haren Gitte, Cohen Arieh, Sommer Helle Molgaard, Dragsted Lars Ove, Tjonneland Anne, Hougaard David Michael, Vogel Ulla
Abstract excerpt
BACKGROUND: Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving peroxisome proliferator-activated receptor gamma (PPARγ) in a complex with peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) and interaction with aromatase (encoded by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.