Article
Correlation of HER2, FCGR2A, and FCGR3A gene polymorphisms with trastuzumab related cardiac toxicity and efficacy in a subgroup of patients from UNICANCER-PACS 04 trial.
Breast cancer research and treatment - 1 Jun 2013
Roca Lise, Diéras Véronique, Roché Henri, Lappartient Emmanuelle, Kerbrat Pierre, Cany Laurent, Chieze Stéphanie, Canon Jean-Luc, Spielmann Marc, Penault-Llorca Frédérique, Martin Anne-Laure, Mesleard Christel, Lemonnier Jérôme, de Cremoux Patricia
Abstract excerpt
The purpose of this study was to investigate, in the context of a prospective node-positive-breast cancer trial HER2 containing-regimen (UNICANCER-PACS 04 trial), the predictive value of HER2, FCGRIIA, and FCGRIIIA gene polymorphisms for cardiac toxicity and efficacy of trastuzumab. We analyzed HER2-I655V, FCGR2A-H131R, and FCGR3A-V158F single nucleotide polymorphisms in patients in adjuvant setting treated by...
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