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Article

Targeted DNA and RNA sequencing of fine-needle biopsy FFPE specimens in patients with unresectable hepatocellular carcinoma treated with sorafenib.

Oncotarget - 28 Aug 2015

Sakai Kazuko, Takeda Haruhiko, Nishijima Norihiro, Orito Etsuro, Joko Kouji, Uchida Yasushi, Izumi Namiki, Nishio Kazuto, Osaki Yukio

Abstract excerpt

The multi-kinase inhibitor sorafenib is now used as standard therapy for advanced hepatocellular carcinoma (HCC). Predictive biomarkers of response to sorafenib are thus necessary. The purpose of this study was to assess the feasibility of using targeted DNA and RNA sequencing to elucidate candidate biomarkers of sorafenib response using fine-needle biopsy, formalin-fixed paraffin-embedded (FFPE) specimens in...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26046304
DOI: 10.18632/oncotarget.4270
PMCID: PMC4673292

Genes

CTNNB1
NRG1
PECAM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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