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Article

Validation of multi-gene panel next-generation sequencing for the detection of BRCA mutation in formalin-fixed, paraffin-embedded epithelial ovarian cancer tissues.

Taiwanese journal of obstetrics & gynecology - 1 Jan 2023

Kim Eun Taeg, Jeong Ha Eun, Yoon Hyung Joon, Kim Ki Hyung, Suh Dong Soo

Abstract excerpt

OBJECTIVE: The therapeutic effect of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with epithelial ovarian cancer (EOC) with somatic BRCA mutations is consistent with that observed in patients with germline BRCA mutations, indicating the importance of detecting both germline and somatic BRCA mutations concurrently. We compared the efficacy of multi-gene panel next generation sequencing (NGS) in EOC...

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Identifiers

PMID: 36720553
DOI: 10.1016/j.tjog.2022.07.010

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