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Targeted and exome sequencing identified somatic mutations in hepatocellular carcinoma

6 Feb 2016

Abstract excerpt

AIM: Genetic analysis has revealed a subset of recurrently mutated genes and aberrant cellular signaling pathways in hepatocellular carcinoma. To investigate genetic alterations and dysregulated pathways in hepatocellular carcinoma, we performed targeted sequencing and exome analysis using next-generation sequencer. METHODS: We analyzed the somatic mutational profiles of 16 genes in primary hepatocellular...

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PMID: 26850916
DOI: 10.1111/hepr.12663

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