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Mucin 1 Regulates Cox-2 Gene in Pancreatic Cancer

2 Jun 2015

Abstract excerpt

OBJECTIVE: Eighty percent of pancreatic ductal adenocarcinomas (PDAs) overexpress mucin 1 (MUC1), a transmembrane mucin glycoprotein. MUC1(high) PDA patients also express high levels of cyclooxygenase 2 (COX-2) and show poor prognosis. The cytoplasmic tail of MUC1 (MUC1-CT) partakes in oncogenic signaling, resulting in accelerated cancer progression. Our aim was to understand the regulation of Cox-2 expression by...

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PMID: 26035123
DOI: 10.1097/mpa.0000000000000371

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