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Article

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells

26 Jun 2007

Abstract excerpt

MUC4 is a type-1 transmembrane glycoprotein and is overexpressed in many carcinomas. It is a heterodimeric protein of 930 kDa, composed of a mucin-type subunit, MUC4alpha, and a membrane-bound growth factor-like subunit, MUC4beta. MUC4 mRNA contains unique 5' and 3' coding sequences along with a large variable number of tandem repeat (VNTR) domain of 7-19 kb. A direct association of MUC4 overexpression has been...

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PMID: 17595659
DOI: 10.1038/sj.bjc.6603868

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