Article
Screening non-deletion α-thalassaemia mutations in the HBA1 and HBA2 genes by high-resolution melting analysis.
Clinical chemistry and laboratory medicine - 1 Nov 2015
Petropoulou Margarita, Poula Amalia, Traeger-Synodinos Jan, Vrettou Christina, Kanavakis Emmanuel, Christopoulos Theodore K, Ioannou Penelope C
Abstract excerpt
BACKGROUND: Screening for "non-deletion" α-chain haemoglobin variants resulting from point mutations or short deletions/insertions has attracted an increased interest during recent years, especially in areas where α-thalassaemia is prevalent. We describe a method utilising high resolution melting analysis for detecting the 13 most common "non-deletion" α-thalassaemia mutations in populations around the...
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